The signs and symptoms of MPM are hard to recognize, as they are often mistaken for other diseases. Sometimes the only sign of MPM is shortness of breath and chest pain, due to the excess fluid in the pleural space.

Other signs that might occur with MPM are:

• Pain under the rib cage.
• Pain or swelling in the abdomen.
• Lumps in the abdomen.
• Weight loss for no known reason.